New research indicates that people who discontinue popular weight-loss injections like semaglutide or tirzepatide can put back on reduced body mass much more quickly than those who stop conventional lifestyle programs.
Research printed in a prominent health publication shows that while obese individuals frequently drop a large proportion of their body weight while using the jabs, the mass is regained at an estimated rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing such drugs should be informed of the potential of quick weight regain when the therapy concludes," stated lead investigator Dr. Susan Jebb.
Such speed of regain implies a return to starting mass in about 18 months.
Weighing Approaches
The research, which examined 37 of studies involving thousands of participants, compared the outcomes of these new drugs with older methods.
Scientists note that people who shed pounds through lifestyle changes alone generally see a less rapid weight regain—perhaps 100 grams monthly—once they finish.
Explaining the Quick Rebound
Experts believe the mode of action of the drugs is key to understanding the amplified rebound.
The injections imitate a body's own chemical called GLP-1, which moderates appetite.
"Long-term administration of the hormone concentrations several times higher than the body's typical production could lead to the system to generate a reduced amount of its endogenous hormone, and may also reduce responsiveness to its effects," said Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this GLP-1 'fix' leads to appetite is uncontrolled, making excessive eating far more likely."
An Ongoing Condition?
Health authorities recommend the jabs for individuals with weight-linked health risks, accompanied by prescribed lifestyle changes.
Professionals contend that, considering the significant potential of relapse, the treatment should be considered long-term.
This perspective is reinforced by pharmaceutical companies, who say that the results "emphasize the persistent nature of excess weight," comparing it to managing diseases like high blood pressure.
Patient Accounts
People who have come off the medication describe a intense return of appetite.
"It was like a switch activating and you're instantly starving," said an individual.
This difficulty is exacerbated if individuals have not developed lasting dietary or behavioural changes during treatment.
Significant Adoption
Recent estimates show that millions of people in the UK have used these injections in the last 12 months, with demand continuing to grow.
- Use is higher among females compared to men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion obtain the drugs through private healthcare rather than the NHS.
In conclusion, experts emphasize that while GLP-1 drugs are potent agents for weight loss, they are not a magic cure and long-term success hinges on combined lifestyle changes.
